AMR is a silent pandemic, threatening to undo a century of medical progress. It transcends human health, intricately linking the well-being of animals and our environment. In response, We are championing stewardship through the One Health lens by launching the ‘IMAGINE ONE HEALTH FRONTIER’—a collaborative platform designed to foster cross-sectoral dialogue, promote responsible antimicrobial use, support research and development in AMR diagnostics, and catalyze investment in surveillance and quality control technologies.